This article was put together with the type assist of Limerick-based mostly analysis assistant in Performance Vitamin and Train Physiologist, Alexandra Cremona. The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-domain proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate a couple of proteins along with histones (see later)