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These tails are topic to a number of put up-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).

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The exception to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and that are structurally not related to SET-area proteins four - 6 Recent work means that SET-area-containing proteins methylate a number of proteins in addition to histones (see later)